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Monkey madness at Oxbridge
Animal Aid's Mad Science Awards (AAMSAs) - handed
out each year for pointless and grotesque scientific research -
never fail to embarrass the animal research community because of
what they reveal to an incredulous outside world.
The theme this year is highly invasive brain research
involving non-human primates at OXFORD and CAMBRIDGE UNIVERSITIES.
These respected seats of learning have traditionally competed against
each other at their annual boat race. This famous event pits top
athletes against each other, epitomising the spirit of human endeavour.
But Oxford and Cambridge are also engaged in an altogether more
contentious form of competition: research on primates.
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This report is also available online in PDF
format.
Photo credit: PETA
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Cambridge
University announced plans in May 2000 to build a massive primate
facility for research into neurological diseases. A subsequent planning
inquiry (in which Animal Aid played a leading part) resulted
in the government inspector ruling decisively against the project
on scientific grounds. The Deputy Prime Minister, however, rejected
the judgement of his own inspector and granted the University permission
to proceed. A High Court challenge,
in July this year, by Animal Aid and the National Anti-Vivisection
Society failed on narrow legal grounds. Meanwhile, the University
- knowing the opposition it faces - has announced that it does not
intend to go ahead after all, despite having permission to do so.
Key sections of the media, however, have portrayed the decision
by Cambridge not to proceed as arising from threats of violence
by animal rights activists. In fact, the University, in its own
evidence to the planning inquiry, insisted that it was not unduly
concerned by animal rights militancy. There was also a failure by
much of the media to reflect the view of members of the scientific
community who gave evidence at the planning inquiry, that primate
research is misleading and counter-productive. Undoubtedly, the
debate over primate research is not only about animal welfare, it
is about good and bad science.
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Unmoved by the Cambridge experience,
Oxford University has begun building
its own £18 million animal research facility. The stated objective
is to seek answers to the problems of heart disease, stroke, cancer
and diabetes. 'Animal models' of these and other human diseases
will be used - a methodology that is now increasingly regarded as
unreliable, even within the research community. Although the project
is currently stalled after the contracted builders
withdrew in the face of concerted campaigning, both the government
and the University are determined not to let the anti-vivisection
movement claim another victory and have pledged that the Oxford
expansion will reach fruition.
The competition between Oxford and Cambridge is not just about
building new research facilities. Rather, it is about actual experiments
currently being conducted on primates in existing Oxbridge laboratories.
Most of these experiments are performed on tiny marmosets and on
rhesus macaques. It is impossible to quantify what suffering these
highly intelligent animals go through before, during and after undergoing
major surgery, the aim of which is to deliberately destroy large
parts of their brains. In addition to experiencing physical pain,
these primates also endure psychological stress and fear.
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Photo credit: Brian Gunn
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| Some of the strongest
scientific arguments against using non-human primates in medical
research have been voiced by individual scientists who themselves
performed animal experiments in the past. A recent example can be
found in a powerful editorial written by Michael Balls (M Balls.
Editorial in ATLA 2003; 31, 545-547.), who made the following
points:
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The use of such highly sentient creatures is morally indefensible
- the main reason for the desire to use them, their similarity
to ourselves, is also a most compelling reason for not doing
so.
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The higher primates, by their very nature, cannot be institutionalised
and remain healthy.
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In my opinion, some of the procedures to be applied to primates
in the new [Cambridge] facility, and especially those involving
the insertion of electrodes into the brain, involve substantial
suffering.
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Similarly, there is little evidence that primates provide effective
models for human disease, especially since insufficient is usually
known either of the human disease, or of its purported relation
in primates, for a rational judgement to be made about how useful
the primate model is likely to be.
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Trying to reproduce animal models of human disease is an outdated
approach, especially since there are now many non-invasive ways
of working with human patients.
- The UK already conducts far more procedures on primates than
any other EU member state [the total number of experiments on
these animals used in Great Britain in 2003 was 4799].
This timely editorial once again highlights the urgent need to
subject the whole issue of primate research to public and scientific
inquiry. For too long, research scientists have been able to pass
off as moderate, procedures that cause severe pain. This is in addition
to the questionable scientific relevance of these experiments to
human patients. |
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Photo credit: ISAV |
| There are other important scientific
arguments against using monkeys as animal models of human brain
diseases.
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Genes in the brain of humans and non-human primates, including
chimpanzees and rhesus monkeys, differ significantly in their
levels of activity. One important difference is that human genes
provide greater protection against activity-related damage,
than do genes in monkey brains. This could help to explain why
humans live longer than non-human primates and also why humans
are more susceptible to age-related neurodegenerative diseases,
such as Alzheimer's and Parkinson's (Emory University Health
Sciences Center press release, 13.10.2003).
- The human brain is about three and a half times bigger than
that of the chimpanzee, our closest evolutionary relative. The
left and right halves of the brain in humans differ from each
other and also differ in their circuitry ('wiring') from chimpanzees.
The key to understanding the differences between the brains of
humans and monkeys is how the brain cells are organised to work
together, which, again, is unique in each species (Brain circuitry
involved in language reveals differences in man, non-human primates.
Medical College of Georgia. 5.9.2001).
Click here for the summaries of
the 2004 award winners >>
Report researched and written by André Menache BSc(Hons)
BVSc MRCVS FRSH, Scientific Consultant to Animal Aid |
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